Cross-Sectional asthma cohort

Overview

Overview
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No description specified

SEEK ID: https://ldh-dzkj.vm.gwdguser.de/projects/10

Public web page: Not specified

Organisms: No Organisms specified

NFDI4Health PALs: No PALs for this Project

Project created: 13th Jul 2026

Extended Metadata (Nfdi4Health MDS 3.3)

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Id of the project(*) : DRKS00004635

Resource classification(*)

Type of the resource : Study

Title(s)/name(s) of the Project

Title/name : SFB/TR 22 - Die allergische Immunantwort der Lunge. Teilprojekt SFB A22
Language of the title/name : German

Title/name : SFB/TR22 - Allergic immune reaction in the lung
Language of the title/name : English

Acronym(s) of the Project

Acronym : SFB A22: CLARA Studie
Language of the acronym : German

Acronym : SFB A22: CLARA study
Language of the acronym : English

Description(s) of the Project

Description : Das allergische Asthma bronchiale im Kindesalter wird als Fehlregulation des Immunsystems zugunsten eines pro-allergischen Th2-Phänotyps beschrieben. Das Th2/Th1-Ungleichgewicht könnte durch eine Fehlregulation der regulatorischen T-Zellen und möglicherweise auch in Interaktion mit den pro-inflammatorischen Th17-Zellen zustande kommen. Klinisch relevant ist neben dem allergischen jedoch auch der nicht-allergische Phänotyp. Der Schwerpunkt dieses Projekts liegt daher auf der Untersuchung der regulatorischen T- und Th17-Zellen in Interaktion mit Th1/Th2-Zellen bei Kindern mit allergischem und nicht-allergischem Asthma bronchiale.
Language of the description : German

Description : Allergic asthma in childhood is described as a dysregulation of the immune system in favor of a pro-allergic Th2 phenotype. The Th2/Th1-imbalance may be mediated by dysregulation of regulatory T cells and potentially also by interaction with pro-inflammatory Th17 cells. Both the allergic and non-allergic asthma phenotype are clinically relevant. The focus of this project is the investigation of regulatory T- and Th17 cells in interaction with Th1/Th2-cells in children with allergic and non-allergic asthma.
Language of the description : English

Keyword(s) describing the Project

Keyword(*) : Not specified

Contributor(s) of the Project

Is it a personal or organisational contribution?(*) : Organisational
Details about the contributing organisation(s)/institution(s)/group(s)
Contributor type(*) : Funder (public)
Funding identifier(s) : Not specified
Name of the organisation/institution/group(*) : Deutsche Forschungsgemeinschaft
Details about the contributing person(s)
Contributor type(*) : Not specified
Given name(*) : Not specified
Family name(s)(*) : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Email address : Not specified
Phone number : Not specified
Organisation(s) associated with the contributor
[]

Is it a personal or organisational contribution?(*) : Personal
Details about the contributing organisation(s)/institution(s)/group(s)
Contributor type(*) : Not specified
Funding identifier(s) : Not specified
Name of the organisation/institution/group(*) : Not specified
Details about the contributing person(s)
Contributor type(*) : Sponsor (primary)
Given name(*) : Bianca
Family name(s)(*) : Schaub
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Email address : bianca.schaub@med.uni-muenchen.de
Phone number : Not specified
Organisation(s) associated with the contributor
Name(*) : Not specified
Address : Not specified
Web page : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Identifier(*) : Not specified
Scheme(*) : Not specified

Is it a personal or organisational contribution?(*) : Personal
Details about the contributing organisation(s)/institution(s)/group(s)
Contributor type(*) : Not specified
Funding identifier(s) : Not specified
Name of the organisation/institution/group(*) : Not specified
Details about the contributing person(s)
Contributor type(*) : Contact
Given name(*) : Bianca
Family name(s)(*) : Schaub
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Email address : bianca.schaub@med.uni-muenchen.de
Phone number : 089/51607781
Organisation(s) associated with the contributor
Name(*) : Not specified
Address : Not specified
Web page : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Identifier(*) : Not specified
Scheme(*) : Not specified

Is it a personal or organisational contribution?(*) : Personal
Details about the contributing organisation(s)/institution(s)/group(s)
Contributor type(*) : Not specified
Funding identifier(s) : Not specified
Name of the organisation/institution/group(*) : Not specified
Details about the contributing person(s)
Contributor type(*) : Principal investigator
Given name(*) : Bianca
Family name(s)(*) : Schaub
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Email address : bianca.schaub@med.uni-muenchen.de
Phone number : 089/5160 7856
Organisation(s) associated with the contributor
Name(*) : Not specified
Address : Not specified
Web page : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Identifier(*) : Not specified
Scheme(*) : Not specified

Is it a personal or organisational contribution?(*) : Personal
Details about the contributing organisation(s)/institution(s)/group(s)
Contributor type(*) : Not specified
Funding identifier(s) : Not specified
Name of the organisation/institution/group(*) : Not specified
Details about the contributing person(s)
Contributor type(*) : Researcher
Given name(*) : Bianca
Family name(s)(*) : Schaub
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Email address : bianca.schaub@med.uni-muenchen.de
Phone number : 089/5160 7856
Organisation(s) associated with the contributor
Name(*) : Not specified
Address : Not specified
Web page : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Identifier(*) : Not specified
Scheme(*) : Not specified

Alternative identifiers

Type of the registry(*) : DRKS
Identifier(*) : DRKS00004635

Characteristics of the Project

Is it an interventional or non-interventional Project? : Non-interventional
Specification of the type of the Project
Interventional Project type : []
Non-interventional Project type : Unknown
Primary health condition(s) or disease(s) considered in the Project
Primary health condition or disease name(*) : Asthma, unspecified
Terminology/classification(*) : ICD-10
Code of the health condition or disease : Not specified
Primary health condition or disease name(*) : Predominantly allergic asthma
Terminology/classification(*) : ICD-10
Code of the health condition or disease : Not specified
Primary health condition or disease name(*) : Mixed asthma
Terminology/classification(*) : ICD-10
Code of the health condition or disease : Not specified
Groups of diseases or conditions(*)
Which groups of diseases or conditions were the data collected on? : Unknown
On which diseases or conditions were the data collected? : []
Collects mortality data? : Not specified
Administrative information about the Project
Status of the ethics committee approval : Request for approval submitted, approval granted
Overall Project status : Other
Participants enrolled by invitation? : Not specified
Start date : 2 February 2010
End date : Not specified
Mono- or multicentric? : Monocentric
Number of centers : Not specified
One or more data providers? : Not specified
Number of data providers : Not specified
Primary subject(*) : Person
Eligibility criteria for Project participants
Eligibility criteria: Minimum age
Minimum eligible age(*) : 4
Unit of age(*) : Years
Eligibility criteria: Maximum age
Maximum eligible age(*) : 14
Unit of age(*) : Years
Eligible gender : Male, Female, Diverse
Inclusion criteria : Inclusion criteria:Age 4-14, recurrent pulmonary infections with airway obstruction / wheeze, more than 3 doctor´s diagnosed obstructive bronchitis. Intake of short-or long- acting beta 2-agonists, inhaled corticosteroides, leukotriene antagonists. Detailed clinical examination including lung-function.
Exclusion criteria : Exclusion criteria for asthmatics:Any other pulmonary diseases (e.g. cystic fibrosis, bronchopulmonary dysplasia), any other chronic diseas, autoimmune diseases, immune deficiency, fever 14 day before inclusion, intake of antibiotics and probiotics 14 day before inclusion, intake of corticosteroides 14 days before inclusion, hypersensitization-therapy ///Exclusion criteria for healthy controls:Any pulmonary diseases (e.g. cystic fibrosis, bronchopulmonary dysplasia), any allergic diseases, any other chronic diseas, autoimmune diseases, immune deficiency, fever 14 day before inclusion, intake of antibiotics or probiotics 14 day before inclusion
Population of the Project(*)
Coverage : Not specified
Country(ies) : Germany
Region(s) and/or city(ies) : Not specified
Interventions of the Project
Name of the intervention(*) : Not specified
Type of the intervention : Not specified
Additional information about the intervention : Not specified
Name(s) of the arm(s) associated with the given intervention : Not specified
Exposures of the Project
Name of the exposure : Not specified
Type of the exposure : Not specified
Additional information about the exposure : Not specified
Name(s) of the group(s) associated with the given exposure : Not specified
Outcome measures in the Project
Name of the outcome measure(*) : Primary outcome
Description of the outcome measure : Characterization of T cell marker
Type of the outcome measure : Primary
Time point(s) of assessment : Not specified
Name of the outcome measure(*) : Secondary outcome
Description of the outcome measure : Characterization of immune regulation in peripheral blood mononuclear cells.
Type of the outcome measure : Secondary
Time point(s) of assessment : Not specified
Additional information about the Project : Not specified
Additional assessments/measurements in the Project : []
Data sharing strategy of the Project(*)
Is it planned to share the data?(*) : Undecided, it is not yet known if data will be made available
Supporting documents available in addition to the data : []
When and for how long will the data be available? : Not specified
Criteria for data access : Not specified
Additional information about data sharing : Not specified
DataSHIELD/Opal infrastructure available? : Not specified
Link to data request application : Not specified
Web page with additional information about data sharing : Not specified
Record linkage possible? : Not specified
Non-interventional aspects of the Project
Temporal design : []
Target follow-up duration of the Project
Target follow-up duration(*) : Not specified
Unit of time(*) : Not specified
Number of follow-ups conducted : Not specified
Biosamples retained in a biorepository : []
Specific types of retained biosamples : Not specified
Interventional aspects of the Project
Numerical phase : Not specified
Masking of intervention(s) assignment
Masking implemented? : Not specified
Who is masked? : []
Additional information about masking : Not specified
Type of allocation of participants to an arm : Not specified
Off-label use of a drug product : Not specified

Cross-Sectional asthma cohort

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