LDH DZKJ

The LISA study is an ongoing, long-term, population-based prospective birth cohort study comprising 3094 children from four regions of Germany (Munich, Leipzig, Wesel, Bad Honnef). The aims of the LISA study are to monitor the development and natural course of atopic diseases and to investigate the influence of life-style and environmental factors. The study further collects information on mental well-being, lung function, nutrition, body composition and physical activity, contributing to a better ...

Das allergische Asthma bronchiale im Kindesalter wird als Fehlregulation des Immunsystems zugunsten eines pro-allergischen Th2-Phänotyps beschrieben. Das Th2/Th1-Ungleichgewicht könnte durch eine Fehlregulation der regulatorischen T-Zellen und möglicherweise auch in Interaktion mit den pro-inflammatorischen Th17-Zellen zustande kommen. Klinisch relevant ist neben dem allergischen jedoch auch der nicht-allergische Phänotyp. Der Schwerpunkt dieses Projekts liegt daher auf der Untersuchung der ...

The GPPAD-04 SINT1A study will evaluate whether early, regular supplementation with a daily dose of a probiotic can reduce the risk of developing beta-cell autoimmunity in children identified by GPPAD-02 as being genetically predisposed to developing type 1 diabetes. Children will be enrolled at age 7 days to 6 weeks (+14 days) and the study product (B. infantis EVC001 or Placebo) will be administered orally once per day from enrollment until age 12 months (+14 days). The hypotheses is that ...

The GPPAD-POInT-Study aims to determine whether daily administration of oral insulin to children from age 4 months - 7 months with elevated genetic risk for type 1 diabetes reduces the cumulative incidence of beta-cell autoantibodies and diabetes in childhood. The purpose of the GPPAD-POInT-Study is to induce immune tolerance to beta-cell autoantigens through regular exposure to oral insulin for a period of 29 to 32 months. Together with the results of the Pre-POINT-Early Study, this phase IIb ...

An Ulm birth cohort study investigating chronic diseases in childhood with a focus on asthma, allergic diseases, obesity, stress and sleep.