Projects

Das allergische Asthma bronchiale im Kindesalter wird als Fehlregulation des Immunsystems zugunsten eines pro-allergischen Th2-Phänotyps beschrieben. Das Th2/Th1-Ungleichgewicht könnte durch eine Fehlregulation der regulatorischen T-Zellen und möglicherweise auch in Interaktion mit den pro-inflammatorischen Th17-Zellen zustande kommen. Klinisch relevant ist neben dem allergischen jedoch auch der nicht-allergische Phänotyp. Der Schwerpunkt dieses Projekts liegt daher auf der Untersuchung der ...

The GPPAD-04 SINT1A study will evaluate whether early, regular supplementation with a daily dose of a probiotic can reduce the risk of developing beta-cell autoimmunity in children identified by GPPAD-02 as being genetically predisposed to developing type 1 diabetes. Children will be enrolled at age 7 days to 6 weeks (+14 days) and the study product (B. infantis EVC001 or Placebo) will be administered orally once per day from enrollment until age 12 months (+14 days). The hypotheses is that ...

The GPPAD-POInT-Study aims to determine whether daily administration of oral insulin to children from age 4 months - 7 months with elevated genetic risk for type 1 diabetes reduces the cumulative incidence of beta-cell autoantibodies and diabetes in childhood. The purpose of the GPPAD-POInT-Study is to induce immune tolerance to beta-cell autoantigens through regular exposure to oral insulin for a period of 29 to 32 months. Together with the results of the Pre-POINT-Early Study, this phase IIb ...

An Ulm birth cohort study investigating chronic diseases in childhood with a focus on asthma, allergic diseases, obesity, stress and sleep.

This resource describes a sub-study (GINI study) as the interventional part of the GINIplus study. Please visit the main resource via the associated resource ID (https://csh.nfdi4health.de/mdr/studyhub_resources/147).

The German Infant Study on the Influence of Nutrition Intervention plus Air pollution and Genetics on Allergy Development (GINIplus) is a multicentre, population-based prospective birth cohort study. The study consists of two arms: an interventional and an observational arm. Both arms together represent a population-based birth cohort. Newborns with family history of allergy were recruited for the interventional arm (GINI = German Infant Nutritional Intervention program, see ...